张亚中.基于超高效液相-四级杆-飞行时间串联质谱的白花蛇舌草注射液主成分分析[J].中草药,2013,44(7):829-833
基于超高效液相-四级杆-飞行时间串联质谱的白花蛇舌草注射液主成分分析
Principal component analysis of Baihuasheshecao Injection by UPLC-QTOF-MS
  
DOI:10.7501/j.issn.0253-2670.2013.07.011
中文关键词:  白花蛇舌草注射液  超高效液相色谱-四级杆-飞行时间串联质谱  主成分分析  物质基础  黄酮类  有机酸
英文关键词:Baihuasheshecao (Hedyotis Diffusae Herba) Injection  UPLC-QTOF-MS  principal component analysis  substantial base  flavonoids  organic acids
基金项目:国家食品药品监督管理局项目(中2011003046001)
作者单位
张亚中 安徽省食品药品检验所安徽 合肥 230051 
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中文摘要:
      目的 探讨全国范围内白花蛇舌草注射液物质基础的差异性。方法 采用超高效液相色谱-四级杆-飞行时间串联质谱(UPLC-QTOF-MS)对16批样品进行测定对采集的数据以保留时间和质荷比作为变量进行主成分分析(PCA)。结果 通过PCA发现不同企业生产的样品自身差异较小相互之间差异较大;通过载荷图分析筛选出对分组影响比较大的7种标记物。结论 全国范围内不同厂家生产的白花蛇舌草注射液不仅颜色差异较大其内在的物质基础也存在明显的差异这种差异主要体现在黄酮类和有机酸类成分的量上。
英文摘要:
      Objective To study the difference of substantial base of Baihuasheshecao (Hedyotis Diffusae Herba) Injection (BSCI) within the nationwide. Methods To determine 16 batches of samples by UPLC-QTOF-MS and analyze the data according to a variety of retention time and m/z by principal component analysis (PCA). Results The results showed that the difference itself was smaller but between each other was bigger among the different enterprises. Seven markers greatly impacted on the components through loading plot analysis were found. Conclusion BSCIs from different enterprises within nationwide are not only obviously different in color but also different in substantial base, which especially indicates the content of flavonoids and organic acids.
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