游 宇,傅超美*,陈秋薇,聂英军,胡慧玲.矿物药玄明粉与无水硫酸钠的构效对比研究[J].中草药,2013,44():
矿物药玄明粉与无水硫酸钠的构效对比研究
Comparative study on the structure and efficacy between weathered sodium sulfate and anhydrous sodium sulfate
  
DOI:
中文关键词:  关键词:玄明粉  无水硫酸钠  结构  药效  晶型
英文关键词:Key words: weathered sodium sulfate  anhydrous sodium sulfate  structure  efficacy  crystal type
基金项目:基金项目:国家中医药管理局行业专项资助项目(201007011-08)
作者单位
游 宇,傅超美*,陈秋薇,聂英军,胡慧玲 成都中医药大学四川 成都 611137 
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中文摘要:
      摘 要:目的 对比研究矿物药玄明粉与无水硫酸钠结构与药效差异,探索两者的作用机制。方法 采用AXIOS 型X 射线 荧光光谱法对两者结构进行比较;采用小鼠胃排空、肠推进模型和复方地芬诺酯所致便秘模型对两者药效进行比较。结果 玄 明粉有正交和立方两种晶型,无水硫酸钠只有正交晶型;除共有化学组成外,玄明粉还含有Al2O3、K2O、SrO、ZnO、Cl, 无水硫酸钠仅有Fe2O3;药效对比试验中,发现两者的药理作用具有显著性差异(P<0.01)。结论 两者在结构和药效上存 在一定的差异,试验结果可为临床应用提供参考依据。
英文摘要:
      Abstract: Objective To prepare salidroside-chitosan nanoparticles (SA-CS-NPs) and to evaluate the properties of in vitro drug release. Methods SA-CS-NPs were firstly prepared by microemulsion-ionic crosslinking method. The particle size and polydispersity of SA-CS-NPs were determined and the morphology of nanoparticles was evaluated. The properties of encapsulation efficiency (EE), load efficiency (LE), and in vitro release of SA-CS-NPs were also evaluated using UPLC method. Resluts The nanoparticles were successfully prepared with the spherical shape or para-spherical shape. The mean particle size was (247.5 ± 23.8) nm with the polydispersity index (PDI) of 0.265 ± 0.071, and the Zeta potential was (23.4 ± 2.7) mV (n = 3). The EE was (70.15 ± 1.60)% and the LE was (14.03 ± 0.32)% (n = 3). The cumulative release rate within 24 h of SA-CS-NPs was over 85%. Conclusion SA-CS-NPs are prepared by microemulsion-ionic crosslinking method show an appropriate particle size and EE, and could exhibit sustained release properties in vitro, which could meet the design requirements.
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