祝倩倩1,萧 伟2*,孙永成2,徐连明2,王 伟2.注射用芪红脉通配液除杂工艺研究[J].中草药,2013,44():
注射用芪红脉通配液除杂工艺研究
Best impurity removal technology of Qihong Maitong Injection intermediatesmixed liquid
  
DOI:
中文关键词:  关键词:芪红脉通  中药注射剂  除杂技术  有关物质  蛋白质
英文关键词:Key words: Traditional Chinese medicine injections  impurity removal technology  related substances  protein
基金项目:基金项目:科技部重大新药创制项目“中药治疗心脑血管疾病有效成分组(群)的创新药物孵化基地”(2011ZX09401-097)
作者单位
祝倩倩1,萧 伟2*,孙永成2,徐连明2,王 伟2 1. 南京中医药大学江苏 南京 210000 2. 江苏康缘药业股份有限公司江苏 连云港 222001 
摘要点击次数: 1038
全文下载次数: 7497
中文摘要:
      摘 要:目的 以注射用芪红脉通为研究对象,确定制剂工艺超滤前最佳除杂技术。方法 考察冷藏、离心、活性炭吸附组 合工艺对药液中杂质及有关物质的去除情况。以黄芪总皂苷、黄芪甲苷、羟基红花黄色素A(HSYA)的质量浓度、固含物 减少率、蛋白质质量浓度、有关物质检查结果等为评价指标,确定除杂方法的可行性并优化工艺参数。结果 最佳工艺参数 为冷藏24 h,离心时间15 min、转速5 000 r/min,活性炭用量0.3%、温度40 ℃、吸附时间30 min、原药液pH 值。结论 冷 藏、离心和活性炭吸附组合工艺除杂效果显著,可有效去除树脂、蛋白质等杂质。
英文摘要:
      Abstract: Objective To determine the best impurity removal technology before ultrafiltration, taking Qihongmaitong injection as the research object. Methods To investigated the removal of impurities and related substances by the combined process of refrigeration, centrifugation, and activated carbon adsorption. Adopting the content of effectual ingredients, solids reduction efficiency, protein content and related substances inspection as the evaluation index to determine the feasibility of the method and optimize the process parameters. Results The experiment showed that the best process parameters were: refrigerated 24 h, centrifugated 15 min, speed 5 000 r/min, activated carbon dosage 0.3%, temperature 40 ℃, adsorpted time of 30 min, the original solution pH value. Conclusion The impurity effect of refrigeration, centrifugation and activated carbon adsorption is significant, which can effectively remove the resin, protein. and other impurity.
HTML  查看全文  查看/发表评论  下载PDF阅读器
关闭
您是第 21629657 位访客
版权所有: 天津中草药杂志社(天津市南开区鞍山西道308号 300193)
Address: 308# An-shan West Road, Nankai District, Tianjin, China Post Code: 300193
Tel: +86-22-27474913; 23006821 Fax: 022-23006821 E-mail:zcy@tiprpress.com
津备案:津ICP备13000267号   互联网药品信息服务资格证书编号:(津)-非经营性-2015-0031