胡绍英1, 2,张振海1,蒋艳荣1,宁 青1,刘其媛1,贾晓斌1, 2*.雷公藤红素胶体二氧化硅缓释固体分散体研究[J].中草药,2013,44():
雷公藤红素胶体二氧化硅缓释固体分散体研究
Studies on sustained release solid dispersion of tripterine carried by colloidal silia
  
DOI:
中文关键词:  关键词:雷公藤红素  胶体二氧化硅  缓释固体分散体  释放速度  释放度
英文关键词:Key words: tripterine  colloidal silia  sustained release solid dispersion  release rate  release
基金项目:基金项目:江苏省中医药领军人才专项基金(2006);“国家中医药管理局中药释药系统重点研究室”开放基金课题(2011NDDCM01002);江苏省高等学校大学生创新训练计划项目(011042004000)
作者单位
胡绍英1, 2,张振海1,蒋艳荣1,宁 青1,刘其媛1,贾晓斌1, 2* 1. 江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室江苏 南京 210028 2. 南京中医药大学江苏 南京 210046 
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中文摘要:
      摘 要:目的 制备雷公藤红素(tripterine)缓释固体分散体,使药物释放度提高,同时缓慢释放药物,以降低其毒副作用。 方法 以胶体二氧化硅为载体,采用溶剂蒸发法制备雷公藤红素固体分散体,对其体外溶出和物相特征进行研究。结果 雷 公藤红素和胶体二氧化硅按1∶12 制备的固体分散体中,药物缓慢释放,8 h 时药物的体外释放度达到90%以上。经差示扫 描量热、X 衍射和电镜分析,固体分散体中药物以非晶形式存在于载体中。结论 雷公藤红素胶体二氧化硅固体分散体制备 工艺简单,药物缓慢释放且释放较完全,具有实际应用价值。
英文摘要:
      Abstract: Objective To prepare the sustained release solid dispersions of tripterine, with the intention of improving drug dissolution. At the same time, the drug releases moderate and performances lower toxicity. Methods Tripterine sustained release solid dispersions was prepared by the solvent method with different weight ratio of colloidal silica dioxide. Its physical characteristics and in vitro release rate were further evaluated. Results The ideal tripterine sustained release solid dispersions was prepared under the condition as follows, the weight ratio of tripterine and colloidal silica dioxide was 1:12, the release rate of drug can keep moderate and controllable. In vitro cumulative release of tripterine sustained release solid dispersion is up to more than 90% after 8 h. Differential scanning calorimetry, scanning electron microscopy and X-ray powder diffraction can prove the tripterine exist as amorphous. Conclusion The sustained release solid dispersions of tripterine, carried by colloidal silica dioxide can controls the release rate of drug keep moderate and controllable, and the preparation process is simple, which has potential applications.
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