张 鲁,李遇伯,李利新,王玉明,许妍妍,靳 晶,张秀秀,张艳军*.制川乌与法半夏不同比例配伍组合对乌头类生物碱的影响[J].中草药,2013,44():
制川乌与法半夏不同比例配伍组合对乌头类生物碱的影响
Contribution of Aconiti Radix Cocta combined with Pinelliae Rhizoma Praeparatum in different ratios to Aconitum alkaloids
  
DOI:
中文关键词:  关键词:制川乌  法半夏  化学计量学  配伍  pH 值
英文关键词:Key words: Aconiti Radix Cocta  Pinelliae Rhizoma Praeparatum  chemometrics  compatibility  pH value
基金项目:基金项目:国家重点基础研究发展计划(“973”计划)(2011CB505300,2011CB505302)
作者单位
张 鲁,李遇伯,李利新,王玉明,许妍妍,靳 晶,张秀秀,张艳军* 天津中医药大学中药学院 天津市中药化学与分析重点实验室天津 300193 
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中文摘要:
      摘 要:目的 研究制川乌与法半夏不同配伍组合中乌头类生物碱的变化趋势,阐明两药配伍后的化学物质基础。方法 采 用LC-MS 技术分析久煎处理的不同配伍组合,结合药液pH 值的变化,运用化学计量学方法寻找、分析差异标记物。结果 制 川乌与法半夏不同配伍组合化学成分含量差异明显,随着法半夏比例的增大,药液pH 值呈上升趋势,乌头类双酯型生物碱 的含量整体呈下降趋势。结论 制川乌与法半夏配伍后毒性物质减少,这可能与法半夏中的某些成分影响了乌头类生物碱的 稳定状态有关。
英文摘要:
      Abstract: Objective To investigate the compatibility taboo theory, the effect of Aconiti Radix Cocta combined with Pinelliae Rhizoma Praeparatum in different ratios on the alkaloids. Methods LC-MS and the pH value were used to analyze the decoctions with different ratios after long time frying, chemometrics was applied to identify the chemical markers. Results There were significant differences in different Aconiti Radix Cocta combined and Pinelliae Rhizoma Praeparatum taboo ratios. The more the Pinelliae Rhizoma Praeparatum’s ratios were, the higher the pH value was. However,the diester diterpene alkaloids’ content was decreasing. Conclusion The chemism may be accessories, which make aconite alkaloids reduce after compatibility process.
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