张秀梅,王国成,王征,陈莹,李德馨,陈德翠.紫杉醇非注射给药系统研究进展[J].中草药,2019,50(17):4020-4030
紫杉醇非注射给药系统研究进展
Research progress on non-injection administration systems of paclitaxel
投稿时间:2019-04-11  
DOI:10.7501/j.issn.0253-2670.2019.17.005
中文关键词:  紫杉醇  非注射给药系统  口服给药系统  阴道给药系统  透皮给药系统  植入释药系统  鼻腔给药系统  生物利用度
英文关键词:paclitaxel  non-parenteral administration  oral administration system  vaginal administration systems  transdermal delivery system  implantable delivery system  intranasal administration system  bioavailability
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作者单位E-mail
张秀梅 天津大学药物科学与技术学院, 天津 300072
天士力控股集团有限公司天士力研究院, 天津 300410 
 
王国成 天士力控股集团有限公司天士力研究院, 天津 300410  
王征 天津大学药物科学与技术学院, 天津 300072 wangzheng2006@tju.edu.cn 
陈莹 天士力控股集团有限公司天士力研究院, 天津 300410  
李德馨 天士力控股集团有限公司天士力研究院, 天津 300410  
陈德翠 天士力控股集团有限公司天士力研究院, 天津 300410  
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中文摘要:
      紫杉醇是从红豆杉中分离出的一种复杂的次生代谢产物,已成为世界公认的强活性广谱抗癌药物。紫杉醇水溶性差,口服生物利用度低,传统注射剂采用聚氧乙烯蓖麻油作为助溶剂,导致过敏反应发生率较高,临床使用前需进行预脱敏处理。因此,紫杉醇非注射给药系统的研究非常活跃,表明临床上对紫杉醇非注射剂型的需求巨大。综述了紫杉醇非注射给药系统的研究进展,包括口服给药系统、阴道给药系统、透皮给药系统、植入释药系统、鼻腔给药系统和吸入给药系统,为今后的研究和临床应用提供参考。
英文摘要:
      Paclitaxel (PTX) is a complex secondary metabolite isolated from Taxus brevifolia, which widely used as chemotherapentic agent with a broad spectrum of actinity against cancer in the world. Its water solubility was poor and oral bioavailability was low. Cremophor-EL was used in traditional PTX injections to improve the solubility of PTX, and resulted in several adverse side effects such as severe hypersensitivity. Pre-desensitization treatment was needed before clinical use. Recently, a variety of non-injection drug delivery systems (DDS) of PTX have been developed. In this paper, the research progress of non-parenteral PTX was reviewed, including oral administration systems, vaginal administration systems, transdermal DDS, implantable DDS, transdermal DDS, intranasal administration and inhalation DDS, so as to provide references for future study and clinical applications.
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