孙 蓉,杨 倩.肾阳虚证动物模型研制进展与中药药效评价的思考[J].药物评价研究,2010,33(1):22-24
肾阳虚证动物模型研制进展与中药药效评价的思考
Advances in establishments of animal models with kidney-yang deficiency syndrome and thinking about efficacy evaluation of Traditional Chinese Medicine
投稿时间:2009-12-12  
DOI:10.7501/j.issn.0253-6376.[year].[issue].[sequence]
中文关键词:  动物模型;药物评价;肾阳虚证
英文关键词:animal model; drug evaluation; Kidney-Yang Deficiency Syndrome
基金项目:重大新药创制新药研究开发关键技术:中药复方药理学研究及药效学评价关键技术(课题编号:2009ZX09502-015)。山东省中医药管理局项目(1999年第03号)。
作者单位
孙 蓉1,杨 倩2 1 山东省中医药研究院,山东 济南 250014; 2 山东中医药大学,山东 济南 250355 
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中文摘要:
      肾阳虚证动物模型是建立最早的中医证侯动物模型,近50年来人们相继运用药物、激素、手术等方法建立了基于西医病理和中医病机的两大类多种肾阳虚动物模型。现有模型研究尚不能完全反映中医肾阳虚证的本质,且造模方法不规范,缺少模型方法学、造模影响因素、造模机理等方面的系列研究,继而影响了温补肾阳药物的合理评价。为了更好地研究肾阳虚证的本质和提供更好的温补肾阳药的评价工具,应在中医理论指导下,以中医临床肾阳虚证的表现为依据,结合现代病因、病机研究,研制更符合临床实际和中医理论的肾阳虚病证结合动物模型。
英文摘要:
      Animal model with Kidney-Yang Deficiency Syndrome was the earliest animal model with traditional Chinese medicine(TCM) syndrome. Many kinds of animal models with Kidney-Yang Deficiency Syndrome were established with drug, hormone and operation successively in recent years. These animal models can be divided into two kinds according to mechanisms of model replicating Methods: pathological model in western medicine and etiological model in traditional Chinese medicine. Available researches on animal model were far from reflecting the essence of Kidney-Yang Deficiency Syndrome completely. The model replicating methods is nonstandard and there is a lack of study of methodology, influencing factors and mechanisms. All these influence the rational evaluation of the drugs of warming and tonifying Kidney-Yang. An animal model with Kidney-Yang Deficiency Syndrome that is more suitable to clinical practice and TCM theory should be made based on the clinical manifestation of Kidney-Yang Deficiency Syndrome and combined with modern research of pathology and etiology. The animal model should be established under the guidance of TCM theory so as to research the essence of Kidney-Yang Deficiency Syndrome and provide a better tool for the evaluation of the drugs of warming and tonifying Kidney-Yang.
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