任晓宇,李廷利.睡眠剥夺与肠道菌群紊乱的关系及改善睡眠药物研发的探讨[J].药物评价研究,2019,42(7):1257-1263
睡眠剥夺与肠道菌群紊乱的关系及改善睡眠药物研发的探讨
Discussion on correlation between sleep deprivation and gut microbiota disorder, research and development of drugs for sleep improvement
投稿时间:2019-03-05  
DOI:10.7501/j.issn.1674-6376.2019.07.001
中文关键词:  睡眠剥夺;肠道菌群紊乱;微生物-脑-肠轴;改善睡眠
英文关键词:sleep deprivation;gut microbiota disorders;microbiota- brain - gut axis;sleep improvement
基金项目:国家自然科学基金面上项目(81274114)
作者单位E-mail
任晓宇 黑龙江中医药大学 药学院, 黑龙江 哈尔滨 150040  
李廷利 黑龙江中医药大学 药学院, 黑龙江 哈尔滨 150040 13804527211@126.com 
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中文摘要:
      肠道菌群作为人体内一个复杂的微生态系统,在维持宿主生理功能上起非常重要的作用,也与许多代谢性疾病、免疫性疾病有着密切的关系。分析睡眠剥夺与肠道菌群紊乱相关性研究的提出和再提出,综合分析肠道菌群紊乱与睡眠障碍的关系,为以肠道菌群为靶点的改善睡眠药物开发及防治方法与思路提供参考。
英文摘要:
      As a comlex microecosystem, gut microbiota plays an important role in maintaining the host physiological function and is also closely related to many metabolic diseases and immune diseases. In this review, we comprehensively analyze the relationship between gut microbiota disorder and sleep disturbances, based on the two times emerging researches of the correlation between sleep deprivation and gut microbiota disorder over the past few decades. The analysis may provide indication for drug development and prevention approaches targeting gut microbiota to improve sleep.
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