梅 雪,余刘勤,陈小云,周春阳.何首乌化学成分和药理作用的研究进展[J].药物评价研究,2016,():
何首乌化学成分和药理作用的研究进展
Advances in studies on the chemical components and pharmacological activities of Radix Polygoni multiflori
投稿时间:2015-08-10  
DOI:
中文关键词:  何首乌;化学成分;药理作用;毒理研究
英文关键词:Polygonum multiflorum; chemical components; pharmacological effects; toxicological studies
基金项目:
作者单位
梅 雪,余刘勤,陈小云,周春阳 川北医学院药学院,四川 南充 637000 
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中文摘要:
      现代研究表明,何首乌化学成分包括蒽醌类、二苯乙烯苷类、磷脂类、酚类和黄酮类等。具有抗衰老、提高免疫力、降血脂、抗动脉粥样硬化、抗炎、抗菌、抗癌、抗诱变等药理作用,毒理作用主要表现为肝脏毒性。以“何首乌”、“化学成分”、“药理学”、“毒理学”、“Polygonum multiflorum”、“Pharmacology”、“Toxicology”为关键词检索中英文数据库,组合查询2000年至2015年在Pubmed、中国知网全文数据库、维普中文期刊全文数据库、万方数据库和读秀数据库中有关何首乌的化学成分、药理作用、毒理学的文献并进行分析、总结和归纳,为进一步研究何首乌化学成分、药理学与毒理学提供参考,为后续药学工作者提供文献依据和研究思路。
英文摘要:
      Chemical constituents of Polygonum multiflorum including anthraquinone glycosides, two styrene, phospholipids, phenols and flavonoids etc. With anti-aging, improve immunity, lowering blood lipids, anti atherosclerosis, anti-inflammatory, antibacterial, anticancer, anti mutagenic and other pharmacological effects, toxicity is mainly manifested as liver toxicity. To Polygonum multiflorum, pharmacology, toxicology as the keywords search in the database, combined query from 2000 to 2015 in PubMed, CNKI full text number according to library, VIP Chinese journal full text database, Wanfang database and Duxiu database related to Polygonum multiflorum chemical constituents, pharmacological activities and toxicology of literature and analysis, summary and induction. To investigate and summarize Polygonum multiflorum chemical constituents, pharmacological and toxicological studies, to provide literature basis and research ideas for further pharmaceutical workers.
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