孟艳秋,张 宇,刘凤鑫,刘文虎,庞舒月.二肽基肽酶Ⅳ抑制剂的药理作用及其机制研究[J].现代药物与临床,2013,28(2):101-107
二肽基肽酶Ⅳ抑制剂的药理作用及其机制研究
Research progress in pharmacologic actions of dipeptidyl peptidase IV inhibitors
  
DOI:10.7501/j.issn.1674-5515.[year].[issue].[sequence]
中文关键词:  二肽基肽酶IV抑制剂  2型糖尿病  降糖  保护心脏  抗炎作用
英文关键词:dipeptidyl peptidase IV inhibitor  type 2 diabetes  hypoglycemic  heart protection  anti-inflammatory action
基金项目:辽宁省重点大学科学研究项目(L2010433)
作者单位E-mail
孟艳秋 沈阳化工大学 制药工程教研室辽宁 沈阳 110142 mengyanqiu@hotmail.com 
张 宇,刘凤鑫,刘文虎,庞舒月   
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中文摘要:
      近些年来,二肽基肽酶Ⅳ(dipeptidyl peptidase IV,DPP-IV)抑制剂在治疗2型糖尿病的药物中异军突起,DPP-IV是一种2型多功能跨膜细胞表面糖基化蛋白,在临床治疗和临床试验中,发现了很多DPP-IV抑制剂潜在的药理作用。通过对国内外相关文献的检索,对DPP-IV抑制剂包括降糖、保护心脏、抗炎等药理作用进行了综述。
英文摘要:
      In recent years, the dipeptidyl peptidase IV (DPP-IV) inhibitors have been used for the treatment of type 2 diabetes. DPP-IV inhibitor is a kind of type 2 multifunctional transmembrane cell surface glycosylation protein, and lots of the potential pharmacological effects of DPP-IV inhibitors have been reported in the clinical treatment and trials. In this paper, the major pharmacological effects of DPP-IV inhibitors including hypoglycemic, cardiovascular system preservation, anti-inflammatory actions, etc. have been summarized through searching the related references at home and abroad.
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