沈淑媛,吴 赟,王成港,王杏林.口腔速溶膜剂的研究进展[J].现代药物与临床,2012,27(3):287-291
口腔速溶膜剂的研究进展
Advances in studies on oral fast dissolving films
  
DOI:10.7501/j.issn.1674-5515.[year].[issue].[sequence]
中文关键词:  口腔速溶膜剂  溶剂浇铸法  热熔挤压法  制剂技术
英文关键词:oral fast dissolving films (OFDF)  solvent casting  hot-melt extrusion  pharmaceutical technology
基金项目:国家重点基础研究发展计划(2010CB735602)
作者单位E-mail
沈淑媛 天津中医药大学天津 3000193 shenshy123@126.com 
吴 赟,王成港 天津药物研究院 释药技术与药代动力学国家重点实验室天津 300193  
王杏林 天津药物研究院 释药技术与药代动力学国家重点实验室天津 300193 wangxl@tjipr.com 
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中文摘要:
      口腔速溶膜剂(oral fast dissolving films,OFDF)是口腔黏膜给药系统中一个新剂型,表现出的许多优点引起广泛的关注,许多制药公司都将快速溶解技术作为一个研究重点。OFDF制剂的生产制备方法主要有溶剂浇铸法和热熔挤压法。目前该制剂产品涉及食品、药品领域,既有治疗口腔疾病的局部药膜,也有发挥全身作用的药膜,由于其独特的剂型优势,许多大公司对此产生浓厚的兴趣,将某些药物进行剂型转换来延长专利期是目前研究的热点。
英文摘要:
      Oral fast dissolving films (OFDF) is a new drug delivery system to oral mucosa. Its obvious advantages have attracted much attention in recent years. Many pharmaceutical companies are now focusing on improving rapid dissolving technology. The preparation methods of OFDF mainly are solvent casting and hot-melt extrusion. So far, OFDF technology is applied in food and medicines not only membrane with focal curing oral diseases but also systemic effects on whole body. Regarding its unique advantages and characteristics, many companies are now considering to transform their branded to OFDFs to extend the patent protection.
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