高 贤,单 淇,辛 宁,侯文彬.长春花化学成分和药理作用研究进展[J].现代药物与临床,2011,26(4):274-277
长春花化学成分和药理作用研究进展
Advances in studies on chemical constituents in Catharanthus roseus and their pharmacological activities
  
DOI:10.7501/j.issn.1674-5515.[year].[issue].[sequence]
中文关键词:  长春花  生物碱  黄酮类  抗肿瘤
英文关键词:Catharanthus roseus  alkaloids  flavanoid  anti-tumor
基金项目:
作者单位E-mail
高 贤 广西中医学院广西 南宁 530001 gxhnxy@126.com 
单 淇 天津药物研究院天津 300193  
辛 宁 广西中医学院广西 南宁 530001  
侯文彬 天津药物研究院天津 300193 houwb@tjipr.com 
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中文摘要:
      长春花属植物是原产于非洲东海岸的野生花卉,现已广泛分布于世界各地。长春花含有萜类生物碱、二聚吲哚生物碱、单吲哚生物碱等多种生物碱类活性成分和黄酮类成分。近年来长春花中单体成分或结构修饰物作为药物被广泛用于治疗多种癌症、糖尿病、高血压及何杰金氏病。综述了近年来对长春花生物碱类和药理活性的研究进展,为更好地开发、利用长春花提供参考。
英文摘要:
      Plants of Catharanthus G.. Don genus are wild flowers which originate from east coast of Africa, and widely distribute all over the world now. There are many kinds of active alkaloids and flavanoid in catharanthus roseus, including terpenoid alkaloid, indole alkaloid dimmers, and indole alkaloid, etc. In recent years, monomer composition or structural modification drugs of Catharanthus plants have been widely used to treat many kinds of cancers, diabetes, and Hodgkin's disease. Since each constituent has much bioactive,the paper summarize research advance in recent years on alkloid composition and pharmacological activity.
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