王同顺,房志仲.复方甘草锌与氨来呫诺口腔复合膜的处方筛选[J].现代药物与临床,2010,25(3):207-210
复方甘草锌与氨来呫诺口腔复合膜的处方筛选
Formulation optimization of compound licorzinc oral complex pellicle
  
DOI:10.7501/j.issn.1674-5515.[year].[issue].[sequence]
中文关键词:  口腔复合膜  甘草锌  氨来呫诺  均匀设计  相关分析  透皮实验
英文关键词:complex pellicle  licorzinc  amlexanox  uniform design  correlation analysis  transdermal test
基金项目:
作者单位E-mail
王同顺 天津医科大学药学院天津 300070  
房志仲 天津医科大学药学院 药剂学教研室天津 300070 fangzhizhong@tijmu.edu.cn 
摘要点击次数: 2227
全文下载次数: 1230
中文摘要:
      目的 采用均匀设计法及相关分析对复方甘草锌与氨来呫诺口腔复合膜的处方进行优选。方法 不同配比的聚乙烯醇(PVA)、羟丙甲基纤维素(HPMC)、丙二醇为成膜材料,以膜剂的柔软性、均匀性、光滑性、透明性作为考察指标,采用均匀设计法及相关分析筛选最优处方并进行透皮吸收试验。结果 最佳成膜材料处方为:PVA 6.5 g,HPMC 0.1 g,丙二醇6.0 g。透皮实验结果表明,甘草锌和氨来呫诺都滞留在皮内,可以更好地促进溃疡面愈合。结论>/b> 采用上述配比的处方可制备出优良的口腔溃疡复合膜,满足缓释、安全的要求。
英文摘要:
      Objective To optimize the prescription of compound licorzinc and Amlexanox oral complex pellicle and improve the quality control by using uniform design and correlation analysis.Methods Different ratio of PVA,HPMC and propylene glycol were used as the composite materials of the pellicleSoftness,uniformity, smoothness, and transparency of the pellicle were regarded as parameters. Uniform design and correlation analysis were adopted for the formulation optimization. Cutaneous absorption test was carried out.Results The optimal formulation of film forming materials was PVA: 6.5 g,HPMC:0.1 g,propylene glycol:6.0 g. The experimental results showed that licorzinc and Amlexanox remained in skin and promoted ulcer healing.Conclusion Preparation of the above prescription can be excellent oral complex pellicle to meet the requirements of slow release and safety.
HTML  查看全文  查看/发表评论  下载PDF阅读器
关闭
您是第 6164914 位访客
版权所有 天津中草药杂志社(天津市南开区鞍山西道308号 300193)
联系电话:022-23006823 传真:022-23006823 E_mail:dc@tiprpress.com
津备案:津ICP备13000267号 互联网药品信息服务资格证书编号:(津)-非经营性-2015-0031