崔秀春,尹维斌,廖中廷,甘敏,常明.红花黄色素氯化钠注射液联合普萘洛尔治疗冠心病心绞痛的临床研究[J].现代药物与临床,2019,34(8):2287-2292
红花黄色素氯化钠注射液联合普萘洛尔治疗冠心病心绞痛的临床研究
Clinical study on Safflower Yellow Sodium Chloride Injection combined with propranolol in treatment of angina pectoris of coronary heart disease
投稿时间:2019-03-28  
DOI:10.7501/j.issn.1674-5515.2019.08.008
中文关键词:  红花黄色素氯化钠注射液  盐酸普萘洛尔片  冠心病心绞痛  血液高凝状态  血小板聚集  心肌耗氧指数  血浆B型利钠肽  ST段压低数值总和
英文关键词:Safflower Yellow Sodium Chloride Injection  Propranolol Hydrochloride Tablets  angina pectoris of coronary heart disease  hypercoagulable state of blood  platelet aggregation  MOCI  BNP  ∑ST
基金项目:
作者单位
崔秀春 资阳市人民医院心血管内科, 四川 资阳 641300 
尹维斌 资阳市人民医院心血管内科, 四川 资阳 641300 
廖中廷 资阳市人民医院心血管内科, 四川 资阳 641300 
甘敏 资阳市人民医院心血管内科, 四川 资阳 641300 
常明 齐齐哈尔医学院附属第一医院心内科, 黑龙江 齐齐哈尔 161006 
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中文摘要:
      目的 探讨红花黄色素氯化钠注射液联合普萘洛尔治疗冠心病心绞痛的临床效果。方法 选取2015年10月—2018年12月资阳市人民医院收治的冠心病心绞痛患者92例,随机分成对照组(46例)和治疗组(46例)。对照组饭后口服盐酸普萘洛尔片,10 mg/次,3次/d。治疗组在对照组基础上静脉滴注红花黄色素氯化钠注射液,100 mL/次,1次/d,滴速应≤30滴/min。两组患者均连续治疗14 d。观察两组患者临床疗效和心电图疗效,同时比较治疗前后两组患者心绞痛发作情况、心电图参数、心肌耗氧指数(MOCI)值、血流变学指标、血小板最大聚集率(MAR)、血浆B型利钠肽(BNP)和C反应蛋白(CRP)水平。结果 经治疗,对照组临床有效率和心电图疗效分别为82.6%和69.6%,均明显低于治疗组的95.7%和87.0%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组心绞痛发作次数、持续时间和硝酸甘油用量均显著下降(P<0.05),且治疗组心绞痛发作情况明显低于对照组(P<0.05)。治疗后,两组心电图各项参数ST段下降导联数(NST)、ST段压低数值总和(∑ST)、心肌缺血时间及MOCI值均显著降低(P<0.05),且治疗组心电图参数和MOCI值明显低于对照组(P<0.05)。治疗后,两组WLV、WHV和PV值较治疗前均显著减小(P<0.05),且治疗组WLV、WHV和PV值明显小于对照组(P<0.05)。治疗后,两组患者MAR值和血浆BNP、CRP水平均显著降低(P<0.05),且治疗组MAR值及BNP、CRP水平明显低于对照组(P<0.05)。结论 红花黄色素氯化钠注射液联合普萘洛尔治疗冠心病心绞痛,能有效控制心绞痛发作,改善患者心电图及心功能,减少心肌耗氧量。
英文摘要:
      Objective To investigate the clinical effect of Safflower Yellow Sodium Chloride Injection combined with propranolol in treatment of angina pectoris of coronary heart disease. Methods Patients (92 cases) with angina pectoris of coronary heart disease in Ziyang People's Hospital from October 2015 to December 2018 were randomly divided into control (46 cases) and treatment (46 cases) groups. Patients in the control group were po administered with Propranolol Hydrochloride Tablets, 10 mg/time, three times daily. Patients in the treatment group were iv administered with Safflower Yellow Sodium Chloride Injection on the basis of the control group, 100 mL/time, dropping speed was less than 30 drops/min, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy and electrocardiogram efficacy were evaluated, and the angina pectoris attack, ECG parameters and MOCI values, hemorheological indexes, MAR value, BNP and CRP levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and electrocardiogram efficacy in the control group were 82.6% and 69.6%, which were significantly lower than 95.7% and 87.0% in the treatment group, respectively, and there were differences between two groups (P<0.05). After treatment, the frequency and duration of angina attack, nitroglycerin dosage in two groups were significantly decreased (P<0.05), and the angina pectoris situation in the treatment group were significantly better than that in the control group (P<0.05). After treatment, the NST, ∑ST, myocardial ischemic time and MOCI value in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the WLV, WHV, and PV values in two groups were significantly decreased (P<0.05), and these values in the treatment group were significantly smaller than those in the control group (P<0.05). After treatment, MAR value, plasma BNP, and CRP levels in two groups were significantly decreased (P<0.05), and these indicators in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Safflower Yellow Sodium Chloride Injection combined with propranolol in treatment of angina pectoris of coronary heart disease can effectively control angina pectoris attack, improve the electrocardiogram and cardiac function and reduce myocardial oxygen consumption.
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