张露,白强黎,辜超.银杏叶胶囊联合前列地尔治疗血管性痴呆的临床研究[J].现代药物与临床,2019,34(7):1984-1987
银杏叶胶囊联合前列地尔治疗血管性痴呆的临床研究
Clinical study on Yinxingye Capsules combined with alprostadil in treatment of vascular dementia
投稿时间:2019-03-22  
DOI:10.7501/j.issn.1674-5515.2019.07.011
中文关键词:  银杏叶胶囊  前列地尔注射液  血管性痴呆  肿瘤坏死因子  成纤维细胞生长因子  不良反应
英文关键词:Yinxingye Capsules  Alprostadil Injection  vascular dementia  TNF-α  FGF  adverse reaction
基金项目:
作者单位
张露 苍溪县人民医院 神经内科, 四川 广元 628400 
白强黎 苍溪县人民医院 神经内科, 四川 广元 628400 
辜超 苍溪县人民医院 神经内科, 四川 广元 628400 
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中文摘要:
      目的 探讨银杏叶胶囊联合前列地尔治疗血管性痴呆的临床疗效。方法 选取2013年10月—2018年9月在苍溪县人民医院治疗的血管性痴呆患者158例,随机分为对照组和治疗组,每组各79例。对照组患者静脉滴注前列地尔注射液,10 μg溶入20 mL生理盐水,1次/d。治疗组在对照组基础上口服银杏叶胶囊,1粒/次,3次/d。两组患者均治疗12周。观察两组患者临床疗效,同时比较治疗前后两组患者认知和日常生活能力、血清炎性因子和不良反应情况。结果 治疗后,对照组和治疗组临床总有效率分别为82.3%和97.5%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者认知功能与日常生活能力评分均显著升高(P<0.05),且治疗组认知和日常生活能力明显高于对照组(P<0.05)。治疗后,两组患者C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)、白介素-6(IL-6)显著降低(P<0.05),治疗组患者成纤维细胞生长因子(bFGF)显著降低(P<0.05),且治疗组患者CRP、TNF-α、IL-6和bFGF水平明显低于对照组(P<0.05)。治疗期间,治疗组不良反应发生率为10.1%,显著低于对照组的22.8%,两种比较差异具有统计学意义(P<0.05)。结论 银杏叶胶囊联合前列地尔治疗血管性痴呆可以更好的改善患者的认知功能与日常生活能力,提升临床疗效,降低不良反应。
英文摘要:
      Objective To investigate the clinical efficacy of Yinxingye Capsules combined with alprostadil in treatment of vascular dementia. Methods Patients (158 cases) with vascular dementia in Cangxi People's Hospital from October 2013 to September 2018 were randomly divided into control and treatment groups, and each group had 79 cases. Patients in the control group were iv administered with Alprostadil Injection, 10 μg added into 20 mL normal saline, once daily. Patients in the treatment group were po administered with Yinxingye Capsules on the basis of the control group, 1 grain/time, three times daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacy was evaluated, and the cognition and daily life ability, the serum inflammatory factors, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 82.3% and 97.5%, respectively, and there were differences between two groups (P<0.05). After treatment, the cognition and daily life ability in two groups was significantly improved (P<0.05), and which in the treatment group was significantly better than that in the control group (P<0.05). After treatment, the serum CRP, TNF-α, and IL-6 levels in two groups were significantly decreased (P<0.05), bFGF in the treatment group was significantly decreased (P<0.05), and the CRP, TNF-α, IL-6, and but bFGF levels in the treatment group were significantly lower than those in the control group (P<0.05). During the treatment, the adverse reactions rate in the treatment group was 10.1%, which was significantly lower than 22.8% in treatment the group, with significant difference between two groups (P<0.05). Conclusion Yinxingye Capsules combined with alprostadil in treatment of vascular dementia can improve the cognitive function and daily life ability, improve the clinical efficacy and reduce adverse reactions.
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