张洪宾,李亮.参七脑康胶囊联合奥扎格雷钠治疗急性脑梗死的临床研究[J].现代药物与临床,2019,34(7):1980-1983
参七脑康胶囊联合奥扎格雷钠治疗急性脑梗死的临床研究
Clinical study on Shenqi Naokang Capsules combined with sodium ozagrel in treatment of acute cerebral infarction
投稿时间:2019-03-04  
DOI:10.7501/j.issn.1674-5515.2019.07.010
中文关键词:  参七脑康胶囊  奥扎格雷钠氯化钠注射液  急性脑梗死  简易智力状态检查量表  血液流变学
英文关键词:Shenqi Naokang Capsules  Sodium Ozagrel and Sodium Chloride Injection  acute cerebral infarction  MMSE  hemorheology
基金项目:
作者单位
张洪宾 天津市宁河区医院 急诊科, 天津 301500 
李亮 沧州市中心医院 急诊医学部, 河北 沧州 061000 
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中文摘要:
      目的 探讨参七脑康胶囊联合奥扎格雷钠氯化钠注射液治疗急性脑梗死的临床疗效。方法 选取2016年1月—2017年12月天津市宁河区医院收治的100例急性脑梗死患者作为研究对象,将患者随机分为对照组和治疗组,每组各50例。对照组患者静脉滴注奥扎格雷钠氯化钠注射液,250 mL/次,2次/d。治疗组在对照组治疗的基础上口服参七脑康胶囊,2 g/次,3次/d。2周为1个疗程,两组均治疗2个疗程。观察两组患者的临床疗效,同时比较两组治疗前后的美国国立卫生研究院卒中量表(NIHSS)评分、简易智力状态检查量表(MMSE)评分、Barthel指数和血液流变学指标。结果 治疗后,治疗组的总有效率为92.00%,显著高于对照组的74.00%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者NIHSS评分显著降低,MMSE评分和Barthel指数显著升高,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组NIHSS评分明显低于对照组,MMSE评分和Barthel指数显著高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者红细胞压积(HCT)、全血高切黏度(HBV)、全血低切黏度(LBV)、血浆比黏度(PV)和纤维蛋白原(FIB)水平均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组患者血液流变学指标水平明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论 参七脑康胶囊联合奥扎格雷钠氯化钠注射液治疗急性脑梗死的具有较好的临床疗效,可改善患者神经损伤情况和血液流变状态,安全性较高,具有一定的临床推广使用价值。
英文摘要:
      Objective To investigate the clinical effect of Shenqi Naokang Capsules combined with Sodium Ozagrel and Sodium Chloride Injection in treatment of acute cerebral infarction. Methods Patients (100 cases) with acute cerebral infarction in Tianjin Ninghe District Hospital from January 2016 to December 2017 were divided into control and treatment groups, and each group had 50 cases. Patients in the control group were iv administered with Sodium Ozagrel and Sodium Chloride Injection, 250 mL/time, twice daily. Patients in the treatment group were po administered with Shenqi Naokang Capsules on the basis of control group, 2 g/time, three times daily. A course of treatment had 2 weeks, and patients were treated for 2 courses. After treatment, the clinical efficacy was evaluated, and the NIHSS, MMSE scores, Barthel index, and hemorheology indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the treatment group was 92.00%, which was significantly higher than 74.00% in the control group, and there were differences between two groups (P<0.05). After treatment, NIHSS in two groups were significantly decreased, but MMSE score and Barthel index were increased, and the difference was statistically significant in the same group (P<0.05). After treatment, NIHSS in the treatment groups were significantly lower than that in the control group, but the MMSE score and Barthel index were higher than those in the control group, with significant difference between two groups (P<0.05). After treatment, HCT, HBV, LBV, PV, and FIB levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the hemorheology indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Shenqi Naokang Capsules combined with Sodium Ozagrel and Sodium Chloride Injection has good clinical efficacy in treatment of acute cerebral infarction, can improve the nerve injury and hemorheological status, with high safety, which has a certain clinical application value.
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