祝叶,林珍,郑忠涛.血栓心脉宁片联合鼠神经生长因子治疗脑梗死的临床研究[J].现代药物与临床,2019,34(7):1976-1979
血栓心脉宁片联合鼠神经生长因子治疗脑梗死的临床研究
Clinical study on Xueshuan Xinmaining Tablets combined with mouse nerve growth factor in treatment of cerebral infarction
投稿时间:2019-03-24  
DOI:10.7501/j.issn.1674-5515.2019.07.009
中文关键词:  血栓心脉宁片  注射用鼠神经生长因子  脑梗死  美国国立卫生研究院卒中量表评分  超氧化物歧化酶  同型半胱氨酸  丙二醛
英文关键词:Xueshuan Xinmaining Tablets  Mouse Nerve Growth Factor for Injection  cerebral infarction  NIHSS score  SOD  Hcy  MDA
基金项目:
作者单位E-mail
祝叶 海口市人民医院 全科医学科, 海南 海口 570208  
林珍 海口市人民医院 全科医学科, 海南 海口 570208  
郑忠涛 海口市人民医院 神经外科, 海南 海口 570208 164877464@qq.com 
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中文摘要:
      目的 研究血栓心脉宁片联合注射用鼠神经生长因子治疗脑梗死的临床疗效。方法 选取2017年11月—2018年11月海口市人民医院接收的60例脑梗死患者作为研究对象,采用随机数字表法将患者分为对照组和治疗组,每组各30例。对照组患者肌肉注射注射用鼠神经生长因子,用2 mL注射用水溶解,1支/次,1次/d;治疗组患者在对照组的基础上口服血栓心脉宁片,2片/次,3次/d。两组患者连续治疗14 d。观察两组患者的临床疗效,同时比较两组治疗前后的美国国立卫生研究院卒中量表(NIHSS)评分和血清学指标。结果 治疗后,治疗组总有效率为93.33%,显著高于对照组的76.67%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者NIHSS评分均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组NIHSS评分显著低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者超氧化物歧化酶(SOD)水平显著升高,同型半胱氨酸(Hcy)和丙二醛(MDA)水平均显著降低(P<0.05);治疗后,治疗组血清学指标水平显著优于对照组(P<0.05)。结论 血栓心脉宁片联合注射用鼠神经生长因子治疗脑梗死具有较好的临床疗效,能够改善患者神经功能和血清学指标水平,具有一定的临床推广应用价值。
英文摘要:
      Objective To study the clinical efficacy of Xueshuan Xinmaining Tablets combined with Mouse Nerve Growth Factor for injection in treatment of cerebral infarction. Methods Patients (60 cases) with cerebral infarction in Haikou People's Hospital from November 2017 to November 2018 were randomly divided into control and treatment groups, and each group had 30 cases. Patients in the control group were im administered with Mouse Nerve Growth Factor for injection, dissolved with 2 mL injection water, 1 tube/time, once daily. Patients in the treatment group were po administered with Xueshuan Xinmaining Tablets on the basis of control group, 2 tablets/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the NIHSS score and serological indicator in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the treatment group was 93.33%, which was significantly higher than 76.67% in the control group, and there were differences between two groups (P<0.05). After treatment, NIHSS scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the NIHSS scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, SOD was significantly increased, but Hcy and MDA levels were significantly decreased (P<0.05). After treatment, the serological indicator levels in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Xueshuan Xinmaining Tablets combined with Mouse Nerve Growth Factor for injection has good clinical efficacy in treatment of cerebral infarction, can improve the neurological function and serological indicator levels of patients, which has a certain clinical application value.
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