陈路熙,黄静.三七通舒胶囊联合鼠神经生长因子治疗急性脑梗死的临床研究[J].现代药物与临床,2019,34(7):1972-1975
三七通舒胶囊联合鼠神经生长因子治疗急性脑梗死的临床研究
Clinical study on Sanqi Tongshu Capsules combined with mouse nerve growth factor in treatment of acute cerebral infarction
投稿时间:2019-04-30  
DOI:10.7501/j.issn.1674-5515.2019.07.008
中文关键词:  三七通舒胶囊  注射用鼠神经生长因子  急性脑梗死  NIHSS评分  Barthel指数评分  血液流变学指标
英文关键词:Sanqi Tongshu Capsules  Mouse Nerve Growth Factor for injection  acute cerebral infarction  NIHSS score  BI score  hemorheology
基金项目:
作者单位
陈路熙 成都市第二人民医院 神经内科, 四川 成都 610000 
黄静 成都市第二人民医院 神经内科, 四川 成都 610000 
摘要点击次数: 57
全文下载次数: 67
中文摘要:
      目的 探讨三七通舒胶囊联合注射用鼠神经生长因子治疗急性脑梗死的临床疗效。方法 选取2015年6月—2018年6月成都市第二人民医院接收的118例脑梗死患者为研究对象,将所有患者采用随机数字表法分为对照组和治疗组,每组各59例。对照组肌肉注射注射用鼠神经生长因子,30 μg溶于氯化钠注射液2 mL中,1次/d;治疗组患者在对照组基础上口服三七通舒胶囊,1粒/次,3次/d。两组患者接受治疗4周。观察两组的临床疗效,比较两组的美国国立卫生研究院卒中量表(NIHSS)评分、Barthel(BI)指数评分和血液流变学指标血浆黏度(CP)、血细胞比容(HCT)和全血高切黏度(HS)水平。结果 治疗后,对照组和治疗组的总有效率分别为84.48%、96.55%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者NIHSS评分显著降低,BI评分显著升高,同组治疗前后比较差异有统计学意义(P<0.05);并且治疗组NIHSS评分和BI评分明显优于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者CP、HCT和HS水平均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);并且治疗组CP、HCT和HS水平明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论 三七通舒胶囊联合注射用鼠神经生长因子治疗急性脑梗死具有较好的治疗效果,能够提高患者神经功能和日常生活能力,改善血液流变学,具有一定的临床推广应用价值。
英文摘要:
      Objective To investigate the clinical efficacy of Sanqi Tongshu Capsules combined with Mouse Nerve Growth Factor for injection in treatment of acute cerebral infarction. Methods Patients (118 cases) with acute cerebral infarction in Chengdu Second People's Hospital from June 2015 to June 2018 were randomly divided into control and treatment groups, and each group had 59 cases. Patients in the control group were intramuscular injection administered with Mouse Nerve Growth Factor for injection, 30 μg added into normal saline 2 mL, once daily. Patients in the treatment group were po administered with Sanqi Tongshu Capsules on the basis of the control group, 1 grains/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and NIHSS scores, BI scores, and hemorrheological parameters in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 84.48% and 96.55%, respectively, and there was difference between two groups (P<0.05). After treatment, NIHSS scores in two groups were significantly decreased, but BI scores in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the scores in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of CP, HCT, and HS in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the hemorheology indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Sanqi Tongshu Capsules combined with Mouse Nerve Growth Factor for injection has clinical curative effect in treatment of acute cerebral infarction, can improve the nervous function and daily living ability of patients, and improve hemorheology, which has a certain clinical application value.
HTML  查看全文  查看/发表评论  下载PDF阅读器
关闭
您是第 5956200 位访客
版权所有 天津中草药杂志社(天津市南开区鞍山西道308号 300193)
联系电话:022-23006823 传真:022-23006823 E_mail:dc@tiprpress.com
津备案:津ICP备13000267号 互联网药品信息服务资格证书编号:(津)-非经营性-2015-0031