徐耀铭,齐晓飞,张国锋,周文静,李莹,山花,郑哲龙,小荣.阿加曲班联合阿司匹林治疗前循环急性脑梗死早期进展的疗效观察[J].现代药物与临床,2019,34(7):1968-1971
阿加曲班联合阿司匹林治疗前循环急性脑梗死早期进展的疗效观察
Clinical observation of argatroban combined with aspirin in treatment of early progression of anterior circulatory acute cerebral infarction
投稿时间:2019-06-12  
DOI:10.7501/j.issn.1674-5515.2019.07.007
中文关键词:  阿加曲班注射液  阿司匹林肠溶片  前循环急性脑梗死早期进展  美国国立卫生研究院卒中量表  Barthel指数
英文关键词:Argatroban Injection  Aspirin Enteric-coated Tablets  early progression of anterior circulatory acute cerebral infarction  NIHSS score  BI score
基金项目:内蒙古自治区科技计划项目(201702130)
作者单位
徐耀铭 通辽市医院 神经内科, 内蒙古 通辽 028000 
齐晓飞 通辽市医院 神经内科, 内蒙古 通辽 028000 
张国锋 通辽市医院 神经内科, 内蒙古 通辽 028000 
周文静 通辽市医院 神经内科, 内蒙古 通辽 028000
内蒙古医科大学附属人民医院, 内蒙古 呼和浩特 010020 
李莹 通辽市医院 神经内科, 内蒙古 通辽 028000 
山花 通辽市医院 神经内科, 内蒙古 通辽 028000 
郑哲龙 通辽市医院 神经内科, 内蒙古 通辽 028000 
小荣 通辽市医院 科教科, 内蒙古 通辽 028000 
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中文摘要:
      目的 探讨阿加曲班注射液联合阿司匹林肠溶片治疗前循环急性脑梗死早期进展的临床疗效。方法 选择2017年10月—2018年9月在通辽市医院治疗的60例前循环急性脑梗死早期进展患者作为研究对象,将所有患者随机分为对照组和治疗组,每组各30例。对照组口服阿司匹林肠溶片,100 mg/次,首剂300 mg,1次/d。治疗组在对照组治疗的基础上前2 d持续微量控制泵入阿加曲班注射液60 mg/d,其余5 d早晚分次微量控制泵入阿加曲班注射液10 mg,泵入间时3 h/次。两组患者均治疗7 d。观察两组患者的临床疗效,同时比较两组治疗前后的美国国立卫生研究院卒中量表评分(NIHSS)和Barthel指数评定量表(BI)评分。结果 治疗后,治疗组的总有效率为86.67%,显著高于对照组的63.33%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组NIHSS评分明显降低,BI指数明显升高,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,治疗组NIHSS、BI评分显著优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 阿加曲班注射液联合阿司匹林肠溶片治疗前循环脑梗死早期进展具有较好的临床疗效,可降低神经功能损伤,改善生活能力,具有一定的临床推广应用价值。
英文摘要:
      Objective To investigate the clinical effect of Argatroban Injection combined with Aspirin Enteric-coated Tablets in treatment of early progression of anterior circulatory acute cerebral infarction. Methods Patients (60 cases) with early progression of anterior circulatory acute cerebral infarction in Tongliao City Hospital from October 2017 to September 2018 were randomly divided into control and treatment groups, and each group had 30 cases. Patients in the control group were po administered with Aspirin Enteric-coated Tablets 100 mg/time, and the first dose was 300 mg, once daily. Patients in the treatment group were continuously pumped Argatroban Injection 60 mg/d for 2 d, and were pumped 10 mg of Argatroban Injection in the morning and evening for 5 d, and the pumping time was 3 h each time. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the NHISS and BI scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the treatment group was 86.67%, which was significantly higher than 63.33% in the control group, and there were differences between two groups (P<0.05). After treatment, NIHSS scores in two groups were significantly decreased, but the BI scores were significantly increased, and the difference was statistically significant in the same group (P<0.05). After treatment, NIHSS and BI scores in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Argatroban Injection combined with Aspirin Enteric-coated Tablets has a good clinical effect in treatment of early progression of anterior circulatory acute cerebral infarction, can reduce neurological impairment and improve living ability, which has a certain clinical application value.
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