雷勇胜,丁文宇,赵丽娜,潘毅,陈蔚.盐酸莫西沙星的单晶制备及其结构表征[J].现代药物与临床,2019,34(7):1941-1946
盐酸莫西沙星的单晶制备及其结构表征
Single crystal culture and structure characterization of moxifloxacin hydrochloride
投稿时间:2019-01-26  
DOI:10.7501/j.issn.1674-5515.2019.07.001
中文关键词:  盐酸莫西沙星  单晶培养  X射线单晶衍射  结构表征
英文关键词:moxifloxacin hydrochloride  single crystal culture  X-ray single crystal diffraction  structure characterization
基金项目:天津市科技计划资助项目(18YFZCSY00090)
作者单位E-mail
雷勇胜 天津药物研究院, 天津 300193  
丁文宇 天津药物研究院, 天津 300193  
赵丽娜 天津药物研究院, 天津 300193  
潘毅 天津药物研究院, 天津 300193  
陈蔚 天津药物研究院, 天津 300193 chenw@tjipr.com 
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中文摘要:
      目的 培养盐酸莫西沙星的单晶,并对其进行结构表征。方法 通过溶剂挥发法制备盐酸莫西沙星单晶,并采用热重分析仪(TGA)–差示扫描量热仪(DSC)和粉末X射线衍射仪(PXRD)对其结晶形态进行了表征。结果 制备得到盐酸莫西沙星无色透明针状结晶。TGA-DSC结果显示盐酸莫西沙星单晶熔点为255℃。单晶X射线衍射结果表明该晶胞属于单斜晶系,P21空间群,分子式为C43H56Cl2F2N6O10,相对分子质量为925.84。结论 采用X射线单晶衍射确证了盐酸莫西沙星单晶的结构,为盐酸莫西沙星的进一步开发提供了研究基础。
英文摘要:
      Objective To cultivate single crystal of moxifloxacin hydrochloride, and to characterize the structure of moxifloxacin hydrochloride. Methods Evaporation methods was applied to grow single crystal of moxifloxacin hydrochloride. The crystal structure of moxifloxacin hydrochloride was studied by X-ray diffraction, and the structure of moxifloxacin hydrochloride was characterized by thermogravimetric analysis (TGA)-differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD). Results Moxifloxacin hydrochloride colorless acicular crystal was obtained. Referring to the TGA-DSC results, the melting temperature of moxifloxacin hydrochloride was determined to be around 255℃. Single crystal X-ray diffractometer confirmed the monoclinic lattice with space group P21 in moxifloxacin hydrochloride. Moreover, the chemical formula and relative molecular mass were C43H56Cl2F2N6O10 and 925.84, respectively. Conclusion The single crystal structure of moxifloxacin hydrochloride is characterized by single crystal X-ray diffractometer, which provides a basis for the further development of moxifloxacin hydrochloride.
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