李真真,高明喜,谢骊,程君,王彦,胡蓉.麝香通心滴丸联合氯吡格雷治疗冠心病心绞痛的临床研究[J].现代药物与临床,2019,34(5):1328-1331
麝香通心滴丸联合氯吡格雷治疗冠心病心绞痛的临床研究
Clinical study on Shexiang Tongxin Dropping Pills combined with clopidogrel in treatment of coronary heart disease with angina pectoris
投稿时间:2019-02-23  
DOI:10.7501/j.issn.1674-5515.2019.05.013
中文关键词:  麝香通心滴丸  硫酸氢氯吡格雷片  冠心病心绞痛  临床症状  血液流变学
英文关键词:Shexiang Tongxin Dropping Pills  Clopidogrel Bisulfate Tablets  coronary heart disease with angina pectoris  clinical symptom  hemorheological index
基金项目:上海市卫生和计划生育委员会(青年)科研课题(20164Y0176)
作者单位E-mail
李真真 上海市第一人民医院宝山分院药剂科, 上海 200940  
高明喜 上海市第一人民医院宝山分院心血管内科, 上海 200940  
谢骊 上海市第一人民医院宝山分院检验科, 上海 200940  
程君 上海市第一人民医院宝山分院药剂科, 上海 200940  
王彦 上海市第一人民医院宝山分院药剂科, 上海 200940  
胡蓉 上海市第一人民医院宝山分院药剂科, 上海 200940 weibage1@163.com 
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中文摘要:
      目的 研究麝香通心滴丸联合硫酸氢氯吡格雷片治疗冠心病心绞痛的临床疗效。方法 选取2015年9月—2018年9月上海市第一人民医院宝山分院收治的124例冠心病心绞痛患者作为研究对象,将患者随机分为对照组和治疗组,每组各62例。对照组患者口服硫酸氢氯吡格雷片,75 mg/次,1次/d;治疗组在对照组治疗的基础上口服麝香通心滴丸,2丸/次,3次/d。两组患者均治疗4周。观察两组患者的临床疗效和心电图疗效,比较两组治疗前后的临床症状缓解情况和血液流变学指标。结果 治疗后,对照组和治疗组的总有效率分别为83.87%、95.16%,两组比较差异具有统计学意义(P<0.05)。治疗后,对照组和治疗组的心电图总有效率分别为82.26%、93.55%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者心绞痛发作次数和持续时间显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组心绞痛发作次数和持续时间显著低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组的全血黏度(WBV)、血浆黏度(PV)、纤维蛋白原(FIB)水平均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组血液流变学指标显著低于对照组,两组比较差异具有统计学意义(P<0.05)。结论 麝香通心滴丸联合硫酸氢氯吡格雷片治疗冠心病心绞痛具有较好的临床疗效,能显著缓解临床症状,改善血液流变学,且安全性较高,具有一定的临床推广应用价值。
英文摘要:
      Objective To study the clinical efficacy of Shexiang Tongxin Dropping Pills combined with Clopidogrel Bisulfate Tablets in treatment of coronary heart disease with angina pectoris. Methods Patients (124 cases) with coronary heart disease with angina pectoris in Baoshan Branch of Shanghai First People's Hospital from September 2015 to September 2018 were randomly divided into control and treatment groups, and each group had 62 cases. Patients in the control group were po administered with Clopidogrel Bisulfate Tablets, 75 mg/time, once daily. Patients in the treatment group were po administered with Shexiang Tongxin Dropping Pills on the basis of the control group, 2 pills/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy and electrocardiogram efficacy were evaluated, and the clinical symptom remission and hemorheological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment group were 83.87% and 95.16%, respectively, and there were differences between two groups (P < 0.05). After treatment, the efficacy of electrocardiogram in the control and treatment groups were 82.26% and 93.55%, respectively, and there was difference between two groups (P < 0.05). After treatment, the angina attack frequency and duration in two groups were significantly decreased, and the difference was statistically significant in the same group (P< 0.05). After treatment, the angina attack frequency and duration in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P< 0.05). After treatment, the levels of WBV, PV, and FIB in two groups were significantly decreased, and the difference was statistically significant in the same group (P< 0.05). After treatment, hemorheological indexes levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P< 0.05). Conclusion Shexiang Tongxin Dropping Pills combined with Clopidogrel Bisulfate Tablets has a good effect in treatment of coronary heart disease with angina pectoris, can alleviate clinical symptoms, improve hemorheology, with high safety, which has a certain clinical application value.
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