金纹宇,朱朋胤,陈洋.丹七软胶囊联合曲美他嗪治疗冠心病心绞痛的临床研究[J].现代药物与临床,2019,34(5):1318-1322
丹七软胶囊联合曲美他嗪治疗冠心病心绞痛的临床研究
Clinical study on Danqi Soft Capsules combined with trimetazidine in treatment of coronary heart disease with angina pectoris
投稿时间:2019-02-15  
DOI:10.7501/j.issn.1674-5515.2019.05.011
中文关键词:  丹七软胶囊  盐酸曲美他嗪片  冠心病心绞痛  血液流变学指标  炎性因子
英文关键词:Danqi Soft Capsules  Trimetazidine Dihydrochloride Tablets  coronary heart disease with angina pectoris  hemorheology index  inflammatory factor
基金项目:
作者单位
金纹宇 海安市人民医院药剂科, 江苏 南通 226600 
朱朋胤 海安市人民医院药剂科, 江苏 南通 226600 
陈洋 海安市人民医院心血管内科, 江苏 南通 226600 
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中文摘要:
      目的 研究丹七软胶囊联合盐酸曲美他嗪片治疗冠心病心绞痛的临床疗效。方法 选取2015年8月—2018年8月海安市人民医院诊治的冠心病心绞痛患者124例作为研究对象,采用随机对照表法将所有患者分为对照组和治疗组,每组各62例。对照组三餐时口服盐酸曲美他嗪片,1片/次,3次/d;治疗组在对照组治疗的基础上口服丹七软胶囊,4粒/次,3次/d。两组患者持续治疗30 d。观察两组患者的临床疗效和心电图疗效,同时比较两组治疗前后的心绞痛发作情况、血液流变学指标和炎性因子水平。结果 治疗后,对照组和治疗组的总有效率分别为80.65%、95.16%,两组比较差异具有统计学意义(P<0.05)。治疗后,对照组和治疗组心电图有效率分别为77.42%、95.16%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者心绞痛发作次数和持续时间均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组心绞痛发作次数和持续时间显著低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者血浆比黏度(PSV)、血细胞比容(HCT)、纤维蛋白原(FIB)和全血黏度(WBV)水平均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组血液流变学指标水平均明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平显著降低,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,治疗组炎性因子水平显著低于对照组,两组比较差异具有统计学意义(P<0.05)。结论 丹七软胶囊联合盐酸曲美他嗪片治疗冠心病心绞痛具有较好的临床疗效,能够改善患者心绞痛发作次数和发作持续时间,降低血液流变学指标水平,安全性较高,具有一定的临床推广应用价值。
英文摘要:
      Objective To study the clinical efficacy of Danqi Soft Capsules combined with Trimetazidine Dihydrochloride Tablets in treatment of coronary heart disease with angina pectoris. Methods Patients (124 cases) with coronary heart disease with angina pectoris in Haian People's Hospital from August 2015 to August 2018 were randomly divided into control and treatment groups, and each group had 62 cases. Patients in the control group were po administered with Trimetazidine Dihydrochloride Tablets at meals, 1 tablet/time, three times daily. Patients in the treatment group were po administered with Danqi Soft Capsules on the basis of control group, 4 grains/time, three times daily. Patients in two groups were treated for 30 d. After treatment, the clinical efficacy and electrocardiogram efficacy in two groups were evaluated, and the attack of angina pectoris, hemorheology indexes, and inflammatory factor level before and after treatment were compared.Results After treatment, the clinical efficacy in the control and treatment group were 80.65% and 95.16%, and there were differences between two groups (P < 0.05). After treatment, the electrocardiogram efficacies in the control and treatment group were 77.42% and 95.16%, and there were differences between two groups (P < 0.05). After treatment, the frequency and duration of angina pectoris in two groups were significantly decreased, and the difference was statistically significant in the same group (P< 0.05). After treatment, the frequency and duration of angina pectoris in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P< 0.05). After treatment, the levels of PSV, HCT, FIB, and WBV in two groups were significantly decreased, and the difference was statistically significant in the same group (P< 0.05). After treatment, hemorheology indexes level in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P< 0.05). After treatment, the levels of TNF-α and CRP in two groups were significantly decreased, and the difference was statistically significant in the same group (P< 0.05). After treatment, inflammatory factor levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P< 0.05). Conclusion Danqi Soft Capsules combined with Trimetazidine Dihydrochloride Tablets has good clinical efficacy in treatment of coronary heart disease with angina pectoris, can improve the frequency and duration of angina pectoris attacks, reduce the levels of hemorheological indicators, with high safety, which has a certain clinical application value.
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