ZHENG Qing-xia,WU Hai-feng,GUO Jian,NAN Hai-jiang,CHEN Shi-lin,YANG Jun-shan,XU Xu-dong.Review of Rhubarbs: Chemistry and Pharmacology[J].Chinese Herbal Medicines (CHM),2013,5(1):9-32
Review of Rhubarbs: Chemistry and Pharmacology
Received:June 07, 2012  Revised:July 30, 2012
DOI:10.7501/j.issn.1674-6384.2013.01.003
中文关键词:  
英文关键词:pharmacokinetic studies  pharmacological activities  quality control  Rheum L.  rhubarb
基金项目:
Author NameAffiliation
ZHENG Qing-xia Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China 
WU Hai-feng Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China 
GUO Jian AstraZeneca Pharmaceuticals, DMPK IM, Waltham, MA 02451, USA 
NAN Hai-jiang Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China 
CHEN Shi-lin Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China 
YANG Jun-shan Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China 
XU Xu-dong Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China 
Hits: 1808
Download times: 7501
中文摘要:
      
英文摘要:
      Rhubarb is a perennial herb belonging to the genus Rheum L. (Polygonaceae). Rhei Radix et Rhizoma (rhubarb roots and rhizomes) is one of the most popular Chinese materia medica and has been widely used for strong laxative function. About 200 compounds with six different types of skeletons (anthraquinone, anthrone, stilbene, flavonoids, acylglucoside, and pyrone) have so far been isolated from eighteen species of the genus Rheum L. These constituents showed extensive pharmacological activities including cathartic, diuretic, anticancer, hepatoprotective, anti-inflammatory, and analgesic effects, as well as toxicological effects. Chemical fingerprint, LC-MS, and other analytical techniques have been used for the quality control of rhubarb. This comprehensive review summarizes the researches into the isolation, pharmacological activities, and phytochemical analysis reported since investigations began in the late 1940s. In addition, pharmacokinetic studies and clinical application of rhubarb are also discussed in present paper.
HTML  View Full Text  View/Add Comment  Download reader
Close
Total Numbers of Visitors 1602970
CopyRight: Tianjin Press of Chinese Herbal Medicines
Address:308# An-shan West Road,Nankai District,Tianjin 300193,China
Tel:+86-22-23006901 Fax::+86-22-23006821 E_mail:chm@tiprpress.com
津备案:津ICP备13000267号 互联网药品信息服务资格证书编号:(津)-非经营性-2015-0031