JIA Yong-liang,ZHAO Jun-ming,ZHANG Lin-hui,SUN Bao-shan,BAO Meng-jing,LI Fen-fen,SHEN Jian,SHEN Hui-jun,ZHAO Yu-qing,XIE Qiang-min.Analgesic and Anti-inflammatory Effects of Ginger Oil[J].Chinese Herbal Medicines (CHM),2011,3(2):150-155
Analgesic and Anti-inflammatory Effects of Ginger Oil
Received:November 18, 2010  Revised:March 07, 2011
DOI:10.3969/j.issn.1674-6384.2011.02.011
中文关键词:  
英文关键词:analgesic activity  anti-inflammatory activity  ginger oil  Zingiber officinale  Zingiberaceae
基金项目:
Author NameAffiliation
JIA Yong-liang Department of Pharmacology, Medical College of Zhejiang University, Hangzhou 310031, China 
ZHAO Jun-ming Liaoning Xinzhong Modern Medicine Co., Ltd., Shenyang 110041, China 
ZHANG Lin-hui Department of Pharmacology, Medical College of Zhejiang University, Hangzhou 310031, China 
SUN Bao-shan Liaoning Xinzhong Modern Medicine Co., Ltd., Shenyang 110041, China 
BAO Meng-jing Department of Pharmacology, Medical College of Zhejiang University, Hangzhou 310031, China 
LI Fen-fen Department of Pharmacology, Medical College of Zhejiang University, Hangzhou 310031, China 
SHEN Jian Department of Pharmacology, Medical College of Zhejiang University, Hangzhou 310031, China 
SHEN Hui-jun Department of Pharmacology, Medical College of Zhejiang University, Hangzhou 310031, China 
ZHAO Yu-qing College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China 
XIE Qiang-min Department of Pharmacology, Medical College of Zhejiang University, Hangzhou 310031, China 
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中文摘要:
      
英文摘要:
      Objective Ginger (Zingiber officinale) is widely used as a spice in cooking and as a medicinal herb in traditional herbal medicine. The present study was to investigate the analgesic and anti-inflammatory activities of ginger oil in experimental animal models. Methods The analgesic effect of the oils was evaluated by the “acetic acid” and “hot-plate” test models of pain in mice. The anti-inflammatory effect of the oil was investigated in rats, using rat paw edema induced by carrageenan, adjuvant arthritis, and vascular permeability induced by bradykinin, arachidonic acid, and histamine. Indomethacin (1 mg/kg), Aspirin (0.5 g/kg) and Dexamethasone (2.5 mg/kg) were used respectively as reference drugs for comparison. Results The ginger oil (0.25-1.0 g/kg) produced significant analgesic effect against chemically- and thermally-induced nociceptive pain stimuli in mice (P < 0.05, 0.01). And the ginger oil (0.25-1.0 g/kg) also significantly inhibited carrageenan-induced paw edema, adjuvant arthritis, and inflammatory mediators-induced vascular permeability in rats (P < 0.05, 0.001). Conclusion These findings confirm that the ginger oil can be used to treat pain and chronic inflammation such as rheumatic arthritis.
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