ZHU Qin-wei,KRAEMER Alexander,ZHU Xu-xiang.Bioactivities and Pharmaceutical Effects of 1-Aminocyclopro- panecarboxylic Acid[J].Chinese Herbal Medicines (CHM),2010,2(2):81-105
Bioactivities and Pharmaceutical Effects of 1-Aminocyclopro- panecarboxylic Acid
Received:October 20, 2009  Revised:March 12, 2010
DOI:10.3969/j.issn.1674-6384.2010.02.001
中文关键词:  
英文关键词:1-aminocyclopropanecarboxylic acid  bioactivities  cerebro- and cardiovascular  neurological protection  non-protein acid  pharmaceutical effects
基金项目:
Author NameAffiliation
ZHU Qin-wei Faculty of Public Health, Bielefeld University, Bielefeld 33615, GermanyJadavpur University, Kolkata 700032, India 
KRAEMER Alexander Faculty of Public Health, Bielefeld University, Bielefeld 33615, GermanyJadavpur University, Kolkata 700032, India 
ZHU Xu-xiang Faculty of Public Health, Bielefeld University, Bielefeld 33615, GermanyJadavpur University, Kolkata 700032, India 
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中文摘要:
      
英文摘要:
      Objective The 1-aminocyclopropanecarboxylic acid (ACPC) is a natural micromolecule non-protein amino acid that exists only in plants. Despite the determination of its regulating effects on plants, several bioactivities and effects on animals or humans are still unclear. This review focuses the pharmaceutical effects,above all, the neuroprotective effects of ACPC on the cerebro- and cardiovascular system. Methods Two hundred and seventy nine studies were selected and identified from a total of 2457 references in Medline and Chemical Abstracts from 1957 to 2008. Only 38 articles on neuroprotective effects of ACPC from seven different countries qualified to be included in the analysis. Results ACPC has altogether following six general neuroprotective effects on the brain and nervous system: anti-neurotoxicity induced by NMDA, dynorphin-A, glutamate, and morphine; protection from cerebral neurological injury induced by ischemia; antidepressant and anxiolytic effects; anti-convulsion and -seizures and control of epilepsy; facilitation of spatial learning and memory; and the effect of reducing alcohol consumption. Conclusion ACPC has shown a variety of effects on plants and animals. The bioactivities and pharmaceutical effects on animals are of great significance to medical research and public health. Further clinical trials or epidemiological studies are needed to determine its effect in humans. Food intervention with ACPC-rich vegetables and fruits may be a suitable therapy for cerebro- and cardiovascular system diseases. Administration of trace exogenous ACPC could produce vegetables and fruits of rich endogenous ACPC.
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