Wan-Jin?Suna, b,Peng?Zhanga, b,Xiang-Wei?Qua, b,Li-Min?Xuc,Chun-Bao?Yangc,Shi-Ping?Gua, b.Formulation optimization, in situ intestinal absorption and permeability of psoralen and isopsoralen[J].Chinese Herbal Medicines (CHM),2019,11(3):
Formulation optimization, in situ intestinal absorption and permeability of psoralen and isopsoralen
  
DOI:10.1016/j.chmed.2019.03.006
中文关键词:  
英文关键词:desirability function  D-optimal design  Iisopsoralen  optimization  psoralen  self-emulsifying drug delivery system
基金项目:
Author NameAffiliation
Wan-Jin?Suna, b aHubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China bHubei Province Academy of Traditional Chinese Medicine, Wuhan 430074, China 
Peng?Zhanga, b aHubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China bHubei Province Academy of Traditional Chinese Medicine, Wuhan 430075, China 
Xiang-Wei?Qua, b aHubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China bHubei Province Academy of Traditional Chinese Medicine, Wuhan 430076, China 
Li-Min?Xuc cThe 264 Hospital of the People's Liberation Army, Taiyuan 030000, China 
Chun-Bao?Yangc cThe 264 Hospital of the People's Liberation Army, Taiyuan 030000, China 
Shi-Ping?Gua, b aHubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China bHubei Province Academy of Traditional Chinese Medicine, Wuhan 430076, China 
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中文摘要:
      
英文摘要:
      Objective To optimize a self-emulsifying drug delivery system (SEDDS) formulation for psoralen and isopsoralen (PSO and IPSO) isolated from Psoraleae Fructus. Methods A D-optimal design was used to investigate the influence of oil percentage, surfactant percentage and cosurfactant percentage on several properties of SEDDS including particle size, polydispersity, equilibrium solubility, in situ intestine absorption rate and intestinal permeability. Furthermore, the desirability function approach was applied to obtain the optimal formulation for the system. Results The oil percentage, surfactant percentage and cosurfactant percentage were optimized to be 53.6%, 35.7% and 10.7%, respectively, which means the model is available. Conclusions The D-optimal design is valuable to optimize the SEDDS formulation and understand formulation compositions’ functions on SEDDS properties.
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