Sidhra Syed Zameer Ahmeda,Syed Zameer Ahmed Khadera, ?,Krishnaveni Radhakrishnana,Vanmathi Marimuthua,Muniraj Chinnusamyb,Venkatesan Thangavelb,Karamchand Ravia,Manimaran Vetrivela.Antiobesity and antihyperlipodemic effect of Ixora coccinea on Triton X-100 induced hyperlipidemia in rats: An approach to evaluate asymmetrical temperature distribution analysis using thermography[J].Chinese Herbal Medicines (CHM),2019,11(3):
Antiobesity and antihyperlipodemic effect of Ixora coccinea on Triton X-100 induced hyperlipidemia in rats: An approach to evaluate asymmetrical temperature distribution analysis using thermography
  
DOI:10.1016/j.chmed.2019.05.006
中文关键词:  
英文关键词:anti-oxidant  hyperlipidemia  Ixora coccinea?Curtis  obesity  thermography  Triton X-100
基金项目:
Author NameAffiliation
Sidhra Syed Zameer Ahmeda aDepartment of Biotechnology, K.S. Rangasamy College of Technology, Tiruchengode, Tamil Nadu 637215, India 
Syed Zameer Ahmed Khadera, ? aDepartment of Biotechnology, K.S. Rangasamy College of Technology, Tiruchengode, Tamil Nadu 637215, India 
Krishnaveni Radhakrishnana aDepartment of Biotechnology, K.S. Rangasamy College of Technology, Tiruchengode, Tamil Nadu 637215, India 
Vanmathi Marimuthua aDepartment of Biotechnology, K.S. Rangasamy College of Technology, Tiruchengode, Tamil Nadu 637215, India 
Muniraj Chinnusamyb bDepartment of Electrical and Electronics Engineering, K.S. Rangasamy College of Technology, Tiruchengode, Tamil Nadu 637215, India 
Venkatesan Thangavelb bDepartment of Electrical and Electronics Engineering, K.S. Rangasamy College of Technology, Tiruchengode, Tamil Nadu 637215, India 
Karamchand Ravia aDepartment of Biotechnology, K.S. Rangasamy College of Technology, Tiruchengode, Tamil Nadu 637215, India 
Manimaran Vetrivela aDepartment of Biotechnology, K.S. Rangasamy College of Technology, Tiruchengode, Tamil Nadu 637215, India 
Hits: 67
Download times: 0
中文摘要:
      
英文摘要:
      Objective: Obesity and hyperlipidemia is the major cause of many pathological diseases with an increase side effects using allopathic drugs. The present study focuses on the effect of Ixora coccinea on Triton X-100 induced hyperlipidemia in rats and associated complications. Methodology: In vitro radical scavenging activity of I. coccinea was assessed using DPPH, FRAP and hydrogen peroxide. In vivo antiobesity and antihyperlipidimic activity of I. coccinea was tested in Triton X-100 induced hyperlipidemic rats and assessed for its biochemical parameters in blood and tissue samples. The relationship between physiological responses and regulation of body temperature was investigated by using animal surface temperature images captured with infrared camera. Results: The results of mineral analysis, antioxidant, total flavonoid and phenolic content represented high amount of mineral and had the potential to scavenge free radicals tested with DPPH, FRAP and hydrogen peroxide radicals with dose dependent activity. The highest activity was observed in aqueous extract, DPPH with 71.5% inhibition, FRAP with 56.8%, H2O2 with 33% activity at 100?μg/mL concentration. Triton X-100 induced hyperlipidemic rats when treated with I. coccinea aqueous extract showed significant activity by regulating the biochemical parameters and maintaining the lipid profile by decreasing TC, LDL-C, VLDL-C, TG and improving HDL-C levels. Similarly, the elevated levels of creatinine, urea, uric acid, AST, ALT, ALP due to induction of hyperlipidemia, were brought back to near normal levels after treatment with I. coccinea. The levels of tissue anti-oxidants enzymes like SOD and CAT were also found to be improved in treated I. coccinea groups. The whole body asymmetrical temperature distribution analysis showed that significant decreases in temperature was observed in obesity induced groups but a gradual increase in temperature (2% – –5%) was observed after treatment. Conclusion: Thus, the results indicated that I. coccinea can be a drug of choice to decrease the risk of complications associated with hyperlipidemia and obesity.
HTML  View Full Text  View/Add Comment  Download reader
Close
Total Numbers of Visitors 1634455
CopyRight: Tianjin Press of Chinese Herbal Medicines
Address:308# An-shan West Road,Nankai District,Tianjin 300193,China
Tel:+86-22-23006901 Fax::+86-22-23006821 E_mail:chm@tiprpress.com
津备案:津ICP备13000267号 互联网药品信息服务资格证书编号:(津)-非经营性-2015-0031