Zhi-rua Xu,Chun-hongc Jiang,Si-yangb Fan,Ren-jiea Yan,Ningc Xie,Chun-zhenb, Wu ?.Comparative pharmacokinetics of naringin and neohesperidin after oral administration of flavonoid glycosides from Aurantii Fructus Immaturus in normal and gastrointestinal motility disorders mice[J].Chinese Herbal Medicines (CHM),2019,11(3):
Comparative pharmacokinetics of naringin and neohesperidin after oral administration of flavonoid glycosides from Aurantii Fructus Immaturus in normal and gastrointestinal motility disorders mice
  
DOI:10.1016/j.chmed.2019.03.011
中文关键词:  
英文关键词:gastrointestinal motility disorders  hesperitin  naringenin  naringin  neohesperidin  pharmacokinetics  total flavonoid glycosides from Aurantii Fructus Immaturus
基金项目:
Author NameAffiliation
Zhi-rua Xu aState Key Laboratory of New Drug and Pharmaceutical Processes/Shanghai Professional and Technical Service Center for Biological Material Drugggability Evaluation, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 201203, China 
Chun-hongc Jiang cState Key Laboratory of Innovative Natural Medicine and TCM Injections, Jiangxi Qingfeng Pharmaceutical Co., Ltd., Ganzhou 341000, China 
Si-yangb Fan bState Key Laboratory of New Drug and Pharmaceutical Processes, Department of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 201203, China 
Ren-jiea Yan aState Key Laboratory of New Drug and Pharmaceutical Processes/Shanghai Professional and Technical Service Center for Biological Material Druggability Evaluation, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 201203, China 
Ningc Xie cState Key Laboratory of Innovative Natural Medicine and TCM Injections, Jiangxi Qingfeng Pharmaceutical Co., Ltd., Ganzhou 341000, China 
Chun-zhenb, Wu ? bState Key Laboratory of New Drug and Pharmaceutical Processes, Department of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 201203, China 
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中文摘要:
      
英文摘要:
      Objective: To compare the pharmacokinetics of naringin and neohesperidin after oral administration of Zhishi total flavonoid glycosides (ZSTFG) extracted from Aurantii Fructus Immaturus in normal and gastrointestinal motility disorders (GMD) mice. Methods: ZSTFG was orally given to normal and GMD mice induced by atropine or dopamine. The plasma samples were incubated with β-glucuronidase/sulfatase, the total (free?+?conjugated) naringenin and hesperitin were extracted with acetonitrile. The validated HPLC-MS/MS method was successfully applied to the pharmacokinetic study. Results: The results showed that, compared with the normal group, AUC0–∞, AUC0–t and Cmax for total naringenin and hesperitin were significantly higher (P < 0.01 or P < 0.05), while CLZ/F for total naringenin and hesperitin was significantly lower (P < 0.01) in the GMD group. Tmax, t1/2z, MRT0-t, and MRT0-∞ for naringenin were longer (P < 0.01) in the GMD group than those in the normal group. Conclusion: The results showed that there were significant differences in pharmacokinetic parameters of naringenin and hesperitin between normal and GMD groups. It was suggested that the absorption of naringenin and hesperitin was increased, and the elimination processes of naringenin and hesperitin were slower in the GMD group than the normal group. The data are of value for further pharmacological studies of ZSTFG and would be useful to provide a reference for improving the therapeutic regimen of ZSTFG in clinical trials.
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