Jian-bo?Chen,Mei-jia?Li,Li-xue?Chen,Yin-shi?Sun.Effects of Raphani Semen on anti-fatigue and pharmacokinetics of Panax ginseng[J].Chinese Herbal Medicines (CHM),2019,11(3):
Effects of Raphani Semen on anti-fatigue and pharmacokinetics of Panax ginseng
  
DOI:10.1016/j.chmed.2019.05.001
中文关键词:  
英文关键词:anti-fatigue  interactions  Panax ginseng C. A. Mey.  pharmacokinetics  Raphani Semen
基金项目:
Author NameAffiliation
Jian-bo?Chen Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agriculture Sciences, Changchun 130112, China 
Mei-jia?Li Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agriculture Sciences, Changchun 130113, China 
Li-xue?Chen Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agriculture Sciences, Changchun 130114, China 
Yin-shi?Sun Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agriculture Sciences, Changchun 130115, China 
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中文摘要:
      
英文摘要:
      Objective To explain the phenomenon that Panax ginseng is not compatible with Raphani Semen based on pharmacodynamics and pharmacokinetics. Methods The forced swimming time and biochemical parameters such as blood lactate (BLA), serum urea nitrogen (SUN), and hepatic glycogen (GLU) were determined for anti-fatigue experiment. The UPLC-MS/MS was used to analyze the pharmacokinetics of Rg1, Re, Rb1, and Rd after orally administration of P. ginseng and P. ginseng combined with Raphani Semen to rats. Pharmacokinetic differences of four ginsenosides between single uses of P. ginseng and combined with Raphani Semen were investigated. Results The results showed that Raphani Semen tended to significantly reduce the anti-fatigue activity of P. ginseng. Co-administration of P. ginseng and Raphani Semen had significant effects on the pharmacokinetics of the four ginsenosides in rats compared to that observed with P. ginseng extract alone. The AUC0–12?h values of the four ginsenosides in PG group were higher than the corresponding values in the PR group. It can be inferred that Raphani Semen decreased the blood exposure of the four ginsenosides in rats when it combined with P. ginseng. Conclusion The anti-fatigue activity and pharmacokinetic results showed that Raphani Semen may reduce the pharmacological actions of P. ginseng.
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