Pachiyappan Rajiv Gandhia,Chinnaperumal Kamarajb, ?,Elangovan Vimalkumara,Selvaraj Mohana Roopanc, ?.In vivo antiplasmodial potential of three herbal methanolic extracts in mice infected with Plasmodium berghei NK65[J].Chinese Herbal Medicines (CHM),2019,11(3):
In vivo antiplasmodial potential of three herbal methanolic extracts in mice infected with Plasmodium berghei NK65
  
DOI:10.1016/j.chmed.2019.06.002
中文关键词:  
英文关键词:Aegle marmelos L.  Aristolochia indica L.  Cassia auriculata L.  GC-MS  histopathology  in vivo antiplasmodial potential  Plasmodium berghei (NK65)  Swiss albino mice
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Author NameAffiliation
Pachiyappan Rajiv Gandhia aDivision of Nanobiotechnology, Department of Zoology, Auxilium College (Autonomous) Affiliated to Thiruvalluvar University, Tamil Nadu 632006, India 
Chinnaperumal Kamarajb, ? bDepartment of Biotechnology, Periyar University, Tamil Nadu 636011, India 
Elangovan Vimalkumara aDivision of Nanobiotechnology, Department of Zoology, Auxilium College (Autonomous) Affiliated to Thiruvalluvar University, Tamil Nadu 632006, India 
Selvaraj Mohana Roopanc, ? cChemistry of Heterocycles & Natural Product Research Laboratory,?Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Tamil Nadu 632014, India 
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英文摘要:
      Objective The present study deals with the investigation of antiplasmodial potential of leaf methanolic extract of Aegle marmelos, Aristolochia indica and Cassia auriculata against Plasmodium berghei (NK65) infected mice. Methods The chloroquine-sensitive parasites P. berghei (1?×?106) were inoculated into Swiss albino mice intraperitoneally. The methanol extracts of three herbal plants were orally administered in P. berghei infected mice which were further assessed using the 4 d suppressive test at different doses of 150, 300 and 600?mg/kg per d. Chloroquine (CQ) was used as the standard drug with of 1.25, 2.5 and 5?mg/kg concentrations and was orally administered. Results The leaves of A. marmelos, A. indica, and C. auriculata were found to suppress P. berghei parasitaemia in Swiss albino mice by (67.0 0?±?4.02) %, (72.0 0?± 8.44)% and (52.7 7?±?2.06)% at 600?mg/kg/d with ED50 values of 284.73, 233.77 and 562.48?mg/kg, respectively. These herbal plants increased the mean survival time of infected mice and prevented body weight loss. GC-MS analysis revealed the presence of hentriacontan-16-one (C31H62O) in A. indica extract. The histopathology study showed non-toxic to kidney and liver at 600?mg/kg/body weight. Conclusions Overall results revealed that herbal plants may be active in the development of novel and cheap antimalarial compounds.
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