Kumar Anuj,Rana Akhilesh,Singh Amit,Singh Alok.Bioactivity of methanolic extract of Brassica juncea in animal model of diabetes mellitus[J].Chinese Herbal Medicines (CHM),2019,11(4):434-437
Bioactivity of methanolic extract of Brassica juncea in animal model of diabetes mellitus
  
DOI:10.1016/j.chmed.2019.04.007
中文关键词:  
英文关键词:anti-hyperglycemic  anti-oxidant  Brassica juncea (L.) Czern. etCoss
基金项目:
Author NameAffiliation
Kumar Anuj aDepartment of Pharmacology,Institute of Medical Sciences,Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India 
Rana Akhilesh aDepartment of Pharmacology,Institute of Medical Sciences,Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India 
Singh Amit aDepartment of Pharmacology,Institute of Medical Sciences,Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India 
Singh Alok bDepartment of Pharmacology, All IndiaInstitute of Medical Sciences,Raipur, Chhattisgarh 492099, India 
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中文摘要:
      
英文摘要:
      Objective To study the bioactivity of methanolic extract of Brassica junceaon animal model of diabetes mellitus along with its effect on diabetic and metabolic parameters. Methods Diabetesmellitus was induced in rats by injecting streptozotocin (60mg/kg) intraperitonealy. Blood glucose was measured on day 3by GOD-POD method to confirm the diabetes mellitus. Rats having fasting blood glucose >250 mg/dLwere further selected for study and they were divided into four groups, control, control+streptozotocin, streptozotocin+ metformin(75mg/kg) and streptozotocin+ extract of B. juncea(450mg/kg). Each group consistedof six rats of either sex. Metformin and experimental extract were administered for 21 d. Triglyceride, cholesterol level were measured on day 21 by commercially available kit. Blood glucose was measured on days 7 and 21. Anti-oxidant potential was assessed by estimating extent of lipid peroxidation (LPO) by malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD) and glutathione (GSH) in liver, kidney, pancreas, muscle tissues on day 21. Unpaired and paired student’s t-test were applied for statistical analysis. Results The extract of B. junceashowed significant decrease in blood glucose level on day 21. The treatment group showed significant difference in oxidative stress by increasing SOD and GSH and decreasing LPO and NO activity on day 21. The treatment didn’t show statistically significant difference of cholesterol, and triglycerides level on day 21. Conclusion The study showed anti-hyperglycemic and anti-oxidative properties of methanolic extract of B.juncea.
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