Tong Wang a,b,1,Xin-chi Feng a,1,Li-qin Ding b,Kun Wang a,b,Xu-liu Shi a,b,Li-wei Chai a,b,Yang Li a,b,Feng Qiu a,b*.Metabolic profiling of icaritin in rats using UHPLC-Q/TOF-MS[J].Chinese Herbal Medicines (CHM),2019,11(2):185-191
Metabolic profiling of icaritin in rats using UHPLC-Q/TOF-MS
  
DOI:10.1016/j.chmed.2019.03.008
中文关键词:  
英文关键词:icaritin  metabolites  Metabolynx  rats  UHPLC/Q-TOF-MS/MS
基金项目:
Author NameAffiliation
Tong Wang a,b,1 a School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China b State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 
Xin-chi Feng a,1 a School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 
Li-qin Ding b b State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 
Kun Wang a,b a School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China b State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 
Xu-liu Shi a,b a School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China b State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 
Li-wei Chai a,b a School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China b State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 
Yang Li a,b a School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China b State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 
Feng Qiu a,b* a School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China b State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 
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中文摘要:
      
英文摘要:
      Objective: To identify the in vivo metabolites of icaritin and speculate its metabolic profiling in rats. Methods: The plasma, bile, urine, and feces of rats were collected after orally administration of icaritin at a dose of 100 mg/kg and detected by an ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS/MS) in both positive and negative modes. The data of treated and control groups were compared and analyzed with the aid of Metabolynx XS software. Results: A total of 25 metabolites were identified in the biosamples, and 14 of them were reported for the first time to our knowledge. Conclusion: The main metabolite types of icaritin in rats were glucuronide conjugation, methylation, hydroxylation, reduction, and acetylation.
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