Nian-yun Yang,Liu-ying Wang,Yi-wen Zhang.Immunological Activities of Components from Leaves of Liriodendron chinensis[J].Chinese Herbal Medicines (CHM),2015,7():
Immunological Activities of Components from Leaves of Liriodendron chinensis
英文关键词:active constituents  immunological activity  Liriodendron chinensis
Author NameAffiliation
Nian-yun Yang 1. Department of Pharmacognosy, Nanjing University of Chinese Medicine, Nanjing 210023, China 
Liu-ying Wang 2. Nanjing Hailing Pharmaceutical Co., Ltd., Yangtze River Pharmaceutical Group, Nanjing 210049, China 
Yi-wen Zhang 3. The 306th Hospital of PLA, Beijing 100101, China 
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      Objectives To investigate the anti-inflammatory components from the leaves of Liriodendron chinensis. Methods The 95% alcohol extract from the leaves of L. chinensis was isolated by column chromatography, and the structures of purified compounds were determined by spectral methods. The bioassay was performed through the inhibitory effects on the inflammatory cells activated by lipopolysaccharide (LPS). Results Nine compounds were isolated, including octacosanoic acid (1), stearic acid (2), (2R)-2-hydroxy-N-[(2S,3S,4R,8E)-1,3,4-tri-hydroxyicos-8-en-2-yl]tetracosanamide (3), (2R)-2-hydroxy-N-[(2S,3S,4R,8E)-1-O-β-D-glucopyranosyloxy-3,4-dihydroxy- octadec-8-en-2-yl]eicosanamide (4), (2R)-2-hydroxy-N-[(2S,3S,4R,8E)-1-O-β-D- glucopyranosyloxy-3,4-dihydroxyoctadec-8-en-2-yl]hexadecanamide (5), dicentrinone (6), liriodenine (7), daucosterol (8), and liriodendritol (9) and among which five compounds could significantly lower the content of nitric oxide (NO) from peritoneal macrophages of rats induced by LPS and reduce the splenic lymphocyte proliferation in mice. This is the first report on the occurrence of ceramides and dicentrinone in the plants of Liriodendron Linn. Conclusion The five compounds are likely to be anti-inflammatory compounds concerning to their pronounced inhibitory action on the activated inflammatory cells. This assessment might provide a basis for searching the potent active compounds used for the treatment of inflammation.
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